The Ultimate Guide to CBD: Everything You Need to Know About the Miraculous Health Benefits of Cannabidiol

Over 5 thousand years  ago, the foremost reason why ancient doctors and healers prescribed cannabis was due to its seemingly apparent benefits to medical health. However, the development of modern science has witnessed series of research into the biological healing processes of CBD.


Furthermore, these research studies have also been further extended to various surrounding topics, which include CBD Oil benefits, cannabidiol, THC, and a host of other cannabinoids present in the hemp plant.


In this article, we have curated the latest scientific research studies and stories, as gathered from both doctors and patients, coupled with treatment, advice for specific symptoms. This piece also includes dosage information and suggestions specifically on the recommended types of cannabinoid-based medicines for specific health conditions.


According to a 2016 report from a study conducted on the relationship between cannabinoids and gastrointestinal disorders, it was discovered that there is a need to bring back cannabis-based medicines in order to help in a wide range of gastrointestinal issues in line with the current understanding of neurochemistry.


Despite the current political and social controversies attached to cannabis as a whole, there is a great need for the medical community to realize that the cannabinoid system exists in the body as a ubiquitous signalling system. However, further researches in both clinical and laboratory are still needed in order to fully understand the cannabinoids system and its relation to not only homeostasis but also disease states in general.


The discoveries of these scientists opened the eyes of many to the significance of the endocannabinoid system, as first identified in the mid-1990s by Raphael Mechoulam. Incredibly, this remains one of the most recent discoveries that concerns the endogenous chemical transmitters involved in maintaining both human and animal health.


The word endogenous can be said to be something that is created naturally within the body. Cannabinoids and their receptors are not only found in the brain, but they are present in many of the body organs, which include the skin, immune cells, connective tissues, and so forth. 


While the cannabinoids receptors form an integral part of the many bodily functions, the lists of diseases and illnesses cured by the therapeutic effects of CBD oils are endless. Here, we’ll be taking a look at some of the notable health benefits of CBD oil specifically as it relates to the body’s endocannabinoid systems:

CBD Oil: A Preventative Medicine

Obviously, cannabinoid receptors are exclusively connected to a part of a biological matrix where there is a connection between the brain and other body systems. Since cannabidiol and other compounds are similar to the chemicals produced by the body, they tend to become successfully integrated into numerous synthetic drugs. 


As reported by a research study conducted by Bradley E. Alger, he was quoted as saying, “With complex actions in our immune system, nervous system, and many other body functions, the endocannabinoid system is literally like a bridge that exists between the brain and mind. While the understanding of this system is essential, there is certainly a link that connects the brain activity with the states of physical health and diseases.”


Now, we’ll proceed to take a brief look at some of the health benefits of CBD oil to the entire body system:

Reduced Risk of Diabetes and Obesity

Several research studies have revealed that regular consumers of cannabis tend to record a lower level of body mass index. Apart from that, smaller waist circumference and reduced risk of diabetes and obesity have also been recorded in regular cannabis users. 


According to a report published in the American Journal of Epidemiology in 2011, which involves more than 52,000 participants, it was discovered that the rates of obesity were reduced about one-third lower among cannabis users. Furthermore, in another research study conducted in 2006, CBD was revealed to reduce the incidence of diabetes in laboratory rats. 


One other study revealed that CBD had been shown to have a significant benefit on weight loss as it helps the body to convert white fats into a weight-reducing brown fat, thus promoting sugar metabolism and insulin production.

Better Cholesterol Profiles and Lowered Risk of Cardiovascular Disease

According to a study conducted in 2013, the data of about 4,652 participants were measured on the effect of hemp on metabolism, which compared current and former users of cannabis with people who doesn’t use cannabis at all. This study revealed that current cannabis users recorded high levels of HDL in the blood, which also translates to good cholesterol. 


Before the end of that same year, there was another survey which consists of members of Canada’s Inuit community, and it was discovered that an average of regular cannabis users recorded increased levels of blood HDL levels a reduced LDL.


In a similar animal trial conducted in 2005, scientists revealed that low dose oral hemp reduced the progression rate of atherosclerosis. In the following year, researchers also wrote that the immune-modulatory capacity of hemp was well-grounded in science, and it has a broad therapeutic property in a wide range of health conditions, which includes atherosclerosis.


Similarly, in a 2007 animal study conducted on the effects of hemp also expressed that CBD has potential protective effects during heart attacks. In that same year, more details were published specifically on the involvement of CB1 and CB2 receptors and their potentials in cardiovascular health and illness.

Reduced Cancer Risks

Have you ever thought about the effect of cannabidiol in the prevention of tumors and other cancerous cells prior to their growth? As contained in a report conducted in a 2012 study, animals treated with CBD recorded a significant reduction in the risk of developing colon cancer after being induced with cancer-causing agents in the laboratory. 

Several other studies have also clearly shown the effect of THC on the prevention and reduction of tumours. One such was that of 1996 on animal models, which discovered that the incident of both benign and hepatic adenoma tumours was reduced upon the administration of CBD.


Similarly, in 2015, the medical records of more than eighty-four thousand male patients were analyzed in California, and it was discovered that patients who use cannabis recorded a relatively high rate of bladder cancer. Incredibly, this was perhaps 45 below the norms. In recent times, topical products have been discovered to help in the treatment and prevention of skin cancers. 


However, research is ongoing on the perfect ratio of CBD and THC and the most effective dose level recommended for cancer treatment and prevention.

Maintenance of Brain Health and Creation of Resilience to Trauma and Degeneration

Obviously, cannabinoids are neuro-protective. This implies that they are functional in maintaining and regulating brain health. These effects may be attributed to a number of actions they have on the brain, which includes the elimination of damaged cells, improved efficiency of the mitochondria, and many more.


Furthermore, CBD also works with other antioxidants present in the body in the reduction of glutamate toxicity. Excess glutamate in the body stimulates the body’s nerve cells in the brain to fire. This further results in overstimulation and ultimately leads to the damage or eventual death of these cells.


Hence, cannabinoids are functional in the prevention of brain cell damage while also keeping a healthy and proper functioning of the organs. Further studies have also shown the anti-inflammatory effects of CBD on the brain.


As the brain ages, there is a reduction in the creation of neurons in the brain. In order to maintain proper brain health while also preventing degenerative diseases, there is a great need for the production of new cells.


As contained in the report of a 2008 study, low doses of CBD and THC like cannabinoids lead to the creation of new nerve cells in animal models and aging brains. Apart from that, CBD is also beneficial to the brain as it helps significantly in the prevention of nerve-related diseases such as neuropathy, Alzheimer’s, and many more.

Protection against Bone Diseases and Broken Bones

When it comes to the process of bone metabolism, cannabinoids are considered facilitative. The bone metabolism cycle is a cycle in which new ones replace old bone materials at about 10 per year, which is a critical factor in the maintenance of strong and healthy bones. CBD has been found to obstruct an enzyme that explicitly destroys bone-building compounds in the body. This also helps to significantly reduce the risk of bone-related diseases such as osteoarthritis and osteoporosis.


In both disease conditions, there is a deficiency of new bone and cartilage cells in the body. CBD, however, helps to facilitate the entire process of formation of new bone cells. This is why CBD has been discovered to increase and speed up the rate of healing of broken bones as a result of stronger fracture callus, thus decreasing the possibility of re-fracturing of bones.

Protects and Heals the Skin

According to research, the skin boasts of the highest concentration of CB2 receptors of all the entire body system. CBD when applied topically whether as an infused lotion, salve, oil, or serum, the antioxidants present in CBD oil has a more powerful effect even when compared with vitamin  E and C. 


These antioxidants are capable of repairing damages as a result of free radicals such as ultraviolet rays and environmental pollutants. Cannabinoid receptors are present in the skin, and they tend to be connected to the regulation of oil production in the sebaceous glands.


Cannabis-based topical products are being produced and developed to treat and manage a wide range of skin-related issues such as acne and psoriasis, and they also help to promote faster rates of healing of damaged skins. As a matter of fact, historical evidence reveals that cannabis has been active in terms of wound health both in animals and people from diverse cultures all across the globe. Recently, the use of cannabis concentrated skin products and CBD oils is rapidly gaining much popularity with a large number of well-documented occurrences. 


For instance, people cure skin related diseases like carcinoma and melanoma with topical application of both CBD and THC products. However, the best known of this cannabis application is that of Rick Simpson, who used cannabis oil to cure basal cell carcinoma.

Anti-Inflammatory Benefits of CBD

In numerous early studies, cannabis has been found to possess anti-inflammatory benefits. This compound engages with the endocannabinoid system in many of the body organs and systematically reduces inflammation. The therapeutic potential of cannabis in terms of inflammation reduction is impressively wide-ranging. This is because many of the diseases that affect the body have their roots in inflammation.

Anxiety and Stress

Throughout history, it has been discovered that the use of cannabis and CBD orally remains one of the common applications of plants across various differing cultures. While THC is a component that helps to increase the level of anxiety in some patients, it also helps to reduce anxiety levels in others. 


When present in a high concentration, CBD has the potential to reduce anxiety levels consistently, and several studies conducted on both animals and humans have attested to this fact. This anxiety-reducing property of CBD can be linked to the activities of both limbic and paralimbic brain areas.

How to Take the Medicine: Dosage and Delivery

When it comes to the dosage and delivery of CBD for medicinal use, it is recommended that you work with a health care practitioner. This is particularly essential in order to develop and fine-tune an accurate and effective dosage for specific health conditions. However, if you are educated and aware of the potential therapeutic benefits of CBD, you may also choose to work for yourself as an informed health consultant.


For anxiety, CBD products with a ratio of 20:1 or higher are recommended and administered as either capsule, drops, or edibles. This is due to the high effects of CBD in the reduction of chronic anxiety, treatment of temporary stress as well as protection of the body from the psychological effects of both. Typically, CBD varieties have a high concentration of linalool, a terpene shared with lavender, and have been proven effective in the management of anxiety-related disorders.


In order to test the sensitivity of CBD in the management and treatment of anxiety, it is recommended that you start with a micro-dose and then go up as needed within the dosage range. However, it would be best if you did not resort to the next higher dose until you observe a relief of those symptoms. 


For immediate relief of those symptoms such as panic, stress or anxiety attacks, smoking, and vaporizing of CBD works effectively and efficiently. Through smoking or vaporization of CBD, the medication is said to only last between one and three hours. Whereas, most of the ingested CBD products take about thirty to sixty minutes before you start noticing the effects, and they last for about six to eight hours. 


Vaporizers that utilizes a cartridge filled with a concentration of CO2 are found to be highly effective, and these contain various ratios of CBD to THC levels. Apart from that, herbal vaporizers are also proven effective in their delivery method.

Effectiveness: Current Science- Benefits of CBD for Anxiety

Generally, the Cannabis Health Index (CHI) has been the most popular evidence-based scoring system. It publishes stories and science-based research on cannabis and its effectiveness on various health issues, and it only works based on the research data available. For updated information on the efficacy of CBD on anxiety, you can refer to 


Based on rubrics and eleven other studies, it could be outrightly concluded that cannabis has been rated in the range of possible-to-probable for the effective treatment and management of anxiety.

Depression and Mood Disorders

Clinical depression is a severe disorder that specifically affects the mood. This kind of health condition is characterized by persistent sadness and loss of interest, which in turn leads to a state of decreased appetite and energy and the eventual suicidal thought. Pharmaceuticals used in the treatment of depressions are often aimed at targeting serotonin, a chemical messenger that specifically functions as a mood stabilizer. 


Interestingly, the neural network of the endocannabinoid system also works similarly as serotonin, dopamine, and other chemical messengers. And some research studies have established a link between cannabinoids and serotonin. While a lower dose of THC helps to raise the body’s serotonin levels, high doses could cause a decrease in the serotonin levels, which eventually worsen the condition.


As contained in a 2009 research report, it could be deduced that researchers found a piece of substantial evidence supporting the fact that the endocannabinoid signals as a target for the pharmacotherapy of depression. CBD might be specifically useful for the treatment and management of depression related to chronic stress, which has been proven to decrease the endocannabinoid levels.


How to Take the Medicine: Dosage and Delivery

Typically, CBD products with a ratio of 20:1 or a higher concentration are recommended and administered as edibles, capsules, or drops. Undoubtedly, products that contain Valentine X or Electra 4 are found to be more energizing and help in relieving depression. 


Whenever the issues only lie in low energy, sativa and other stimulating strains could be helpful for the improvement of energy and focus whenever THC can be tolerated. Varieties that have high concentrations of terpenes like limonene are also recommended as they help in mood elevation.  


It is, however, suggested that you always begin with microdose in order to test the sensitivity. Then, you go up as required within the dosage range before going to the next and watch closely as the symptoms subside. The micro to standard dose is one of the most recommended doses for the treatment of depression. 


Vaporized or smoked cannabis are also effective in relieving of immediate symptoms, or a boost in dosage, and it could also help in resolving sleep issues. Often, sublingual sprays or tinctures take quick effects, and they also last longer than inhaled CBD products because they are liquids.


Effectiveness of Cannabis for the Treatment of Depression: The Current Science

A research conducted in 2005 recommended further clinical trials in order to establish the efficacy of cannabinoids in the treatment of bipolar disorders. Similarly, in 2010, a study also suggested that CBD doesn’t have a precise use for manic episodes that are associated with bipolar disorders. However, there is a more significant potential for the effectiveness of CBD for depressive episodes.


Authors of a 2014 review on animal studies concluded that CBD had proven antianxiety and antidepressant effects in several models. More so, they suggested that the compound worked effectively by establishing an interactive link between 5-HT1A neuroreceptors.


Dr. Michael Moskowitz writes, “It is important to remember that CBD benefits and improves the activity in the endocannabinoid system by increasing the time anandamide works on the CB1 and CB2 receptors.” 


Furthermore, he said, “Anandamide works on the serotonin, norepinephrine, and dopamine systems. It also works on the GABA-glutamate system and the hypothalamic-pituitary-adrenal axis. Its main role is restoring balance through inhibition when levels are too high and enhancement when they are too low. This is the most likely reason phytocannabinoids in general and CBD specifically are able to regulate depression and anxiety.”


According to Sir John Russell Reynolds, a neurologist, epilepsy research pioneer and physician to Queen Victoria back in 1859, “for the relief of certain kinds of pain, there is no more useful medicine than Cannabis within our reach.” 


In fact, cannabis has remained the first set of treatment options for the management and treatment of pain relief in many of the ancient civilizations through Asia, the Middle East, Europe, and other parts of the world. The inquiry of scientists and researchers into cannabis has confirmed the effectiveness of this analgesic for numerous kinds of pain. 


Of all the reasons why many people love cannabis today, body pain remains the most common. In the United States, statistics revealed that about seventy million people suffer from chronic pain, and this is defined by experiencing more than one hundred days of pain in a year. However, physicians have made a clear difference between neuropathic and nociceptive pains. 


Cannabis has been proven to work on most neuropathic and many other nociceptive pains. A number of research-based studies have established that the endocannabinoid system can be centrally and peripherally linked with pain processing signals in the body. Most of these discussions supporting the use of cannabis in pain reliefs, however, suggested that it is essential to know the right dosage. 


How to Take the Medicine: Dosage and Delivery

It is highly essential that patients suffering pains and want to adopt the use of CBD should work with competent health care practitioners in order to develop and fine-tune various effective methods of CBD dosage and delivery.


Oral CBD products with a high ratio of 20:1 and higher can be administered in various forms, which includes edibles, capsules, and drops. And these dosage is sufficient enough for the alleviation of pain, specifically the inflammatory type. Most of the earlier discussion on the treatment of pain with cannabis have recommended that patients should use the right kind of dosage in order to establish its effectiveness. 


Usually, it would help if you consider starting with the micro dose since the use of these compounds for pain treatment is sensitive. The micro to standard dose is usually recommended for pain reliefs. However, patients are advised to monitor their conditions carefully and evaluate the appropriate formula; 10–40 mg of CBD or CBD+THC together is usually enough. 


Other cannabinoids that are also effective in the treatment of pains include CBC, THCV, CBG, and THCA. Chemotypes that have a relatively high content of beta-caryophyllene, myrcene, and linalool also provide the body with additional pain relief while also increasing the effectiveness of other cannabinoids for analgesia. 


Effectiveness of CBD in Pain Reliefs: The Current Science

Several research studies have attested to the fact that CBD and cannabis boast of a rating of a highly probable efficacy in the treatment of pains. In fact, the use of cannabis for the alleviation of pain remains the best and most substantiated medicinal use of cannabinoids all across the world today.


Sativex is an oromucosal spray derived from the cannabis plant, and it contains equal proportions of both CBD and THC. This compound has been confirmed and approved in several countries of the world as a result of its effectiveness in the treatment of specific types of pains. 


Numerous randomized clinical studies have also demonstrated the possibility, safety, and efficacy of Sativex for the treatment of illnesses that emanates from both the central and peripheral neuropathic pain. Apart from that, it also works for the treatment of rheumatoid arthritis, cancer pain, and many more.


Cannabinoids influence the transmission of pain signals from the affected region to the brain and back to the affected region. 


According to a study conducted in 2011, CBD and CBC are responsible for stimulating the pain-blocking pathways of the nervous system. Aside from that, it also causes analgesia by establishing a close interaction with several other target proteins that are essential parts of the nociceptive controls. The authors of this research, however, concluded that cannabinoids are responsible for therapeutic agents with multiple mechanisms of action.

Sleep Disorders (Insomnia and Sleep Apnea)

Cannabis and sleep enjoy a complicated relationship, and science is gradually beginning to elucidate further. Generally, indica strains are found to be more relaxing and highly useful for sleep disorders. Whereas the sativa strains are even more stimulating, and they tend to keep people awake.


Several studies and researches held between 2004 and 2008 have established a variable effect of different cannabinoids on sleep. In one of those studies, 15 mg of THC have been found with sedative properties, and 15 mg of CBD has been found to have alerting properties. 


Another study also tested the efficacy of CBD in animal models in both light-filled and light deficient mediums, and it was discovered that non-psychoactive cannabis compounds led to an increase in the alertness when the light was on and recorded an absolutely zero discernable effects on light-deficient sleep. The author of the study also concluded that CBD also boasts of therapeutic potentials for those suffering from excessive daytime sleepiness as a result of sleep deficiency.

How to Take the Medicine for Sleep Disorders: Dosage and Delivery

While CBD is useful for making some patients sleep better, it is also responsible for wakefulness in others. Cannabis products that contain THC strains specifically for the kush or purple varieties have been proven effective for the management and treatment of sleep disorders. This is due to the high contents of linalool and myrcene, a terpene shared with lavender and have been proven effective relaxation. 


When it comes to the reduction of psychoactivity, combinations of cannabis with CBD: THC ratios of 1:1, 4:1, or 24:1 can be administered. For the treatment of sleep disorders, oral consumption is highly recommended. This is because it usually lasts for a whole night. It is, however, better to start with a microdose in order to establish its sensitivity. 


When relaxing, indica strains of cannabis are used with a higher concentration of THC, a minimal dose of 5-10 mg is usually sufficient. In other people, a higher dose of 15-40 mg is recommended. CBD, whether it is taken as tincture of edible, is capable of aiding restful sleep periods, usually between six and seven hours. 


This type of disorder, however, varies considerably from one patient to another. Often, one needs to perform some form of experimental studies and try different ratios of CBD: THC in order to establish the best proportions of CBD oil that is helpful in the treatment of sleep disorders.


Effectiveness of CBD for the Treatment of Sleep Disorders: The Current Science

According to a study conducted in  2007, CBD: THC ratios of 1:1 sprayed on patients shown a positive effect in helping patients, specifically those suffering from chronic pain sleep better. REM sleep behavior disorder is usually characterized by the complete loss of muscle relaxations, specifically during REM sleep. 


The study witnessed four patients as participants, and CBD was used in the conduct of this study. At the end of this study, it was concluded that CBD had a substantial reduction in the frequency of RBD related events without any adverse effect whatsoever.


There you have it! Perhaps an accurate and well-detailed science-based research on various benefits of CBD to both humans and animals.